Cannot say enough good things about Blackjack (2) in multiplayer Innsmouth, a campaign with tons of enemies in the Encounter deck:
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You skip all penalties for engaging with enemies - no taking damage, no taking horror, no losing cards, etc.
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If you care about your fellow investigators, you save an action from not having to engage with enemies
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You deal no damage to your fellow investigators when you miss
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Automatically gets its +1 damage benefit on massive enemies when there's another Investigator in the room (like another attacker or an evader)
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Limitless use (no charges or supplies)
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Only takes up one hand slot
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At just 2 dollars, it's really inexpensive
Want to give it a little extra oomph? Enchant Weapon for +1 damage each round.
The only downside is it doesn't leave you well equipped to handle the enemies that are engaged with you. But that's what guns, Machete, Timeworn Brand, Enchanted Blade, etc. are for, and good news, you still have a handslot for them.
10/10, would Blackjack again.