William Yorick is the one that I am excited about playing out of the box along with Sefina Rousseau (who reminds me of the way that Andromeda was played and provides you with so many options in the early game).
I think that he will play differently, and I can see him focusing on weapons that normally don't see a lot of play such as Knife, Baseball Bat and would likely also carry around a Gravedigger's Shovel or Lantern. He should be designed to stay resource light, but probably shouldn't be playing Dark Horse since he will need resources at a moments notice.
I think 2 good assets for him to consider would be Leather Coat and Stray Cat. These will be great cheap assets to retrieve after defeating an enemy when your Baseball Bat hasn't broken. He could even later be setup as a serious tank with Bulletproof Vest and Elder Sign Amulet if you so decide to go that route, but I probably won't do that myself.
I think he is one of the best people to take advantage of The Red-Gloved Man. He can recur him consistently after defeating enemies if he would like and has the resources to go grab him and bring him into play from survivor cards like A Chance Encounter or Flare even outside the turns where he defeats something. The only downside to bringing out The Red-Gloved Man with his ability is that it won't be for all 3 actions of his turn.
I do think he plays differently and I am excited to try him out.