
Two completely unrelated quotes from the rules:
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"If an investigator with an empty investigator deck needs to draw a card, that investigator shuffles his or her discard pile back into his or her deck, then draws the card, and upon completion of the entire draw takes one horror."
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"A single card cannot be shuffled into an empty player deck or encounter deck via card effect. If this shuffling would occur during the playing or revelation of a card that is typically discarded after it is resolved, such as an event or treachery card, it is discarded. Otherwise, the card remains in its current game area."
Two copies of Quick-Witted are not a single card.
Neither are three Segments of Onyx.
So, I'm thinking: if you draw your deck (at some point, if you're a it shouldn't be a problem), have 2 Quick-Witted in the discard and the last one in your hand, you can cycle them infinitely (provided you have enough resources)
- play all Segments of Onyx, immediately using one charge from the Pendant of the Queen
- investigate committing the last Quick-Witted, shuffling the other two into the deck
- draw for turn (1 card left in the deck afterwards)
- get rid of the Quick-Witted you just drew (commit it, discard it, whatever)
- use second charge from Pendant of the Queen
- draw for turn (no cards left in the deck afterwards)
- use the last charge from Pendant of the Queen, shuffling the Segments of Onyx into the deck
- draw them at your convenience
- repeat from step 1.
Infinite panic button.