There are obvious synergies here with survivor, with Yorick being the best partner for Lieutenant Wilson (although Wendy can have fun too, getting additional benefits from her events). Patrice digs him because she always has the cards to toss. And Norman Withers will absolutely love him, because you know exactly what you’re going to discard.
There are some edge cases where Wilson Stewart becomes neat, like when you scry your own deck and can put your weakness on top… then discard it. Or combine have with the upgraded seeker scroll of secrets, with the potential to discard one weakness, put another on top of your deck, and then discard it, and drawing a card you might actually like.
Or you have a draw heavy character like a rogue with the lucky cigarette case. Know that the bottom of your deck is mostly dregs? Toss it! Or pair with Yaotl!