You might not guess it, but the card with the people bareknuckle boxing is super good with the boxer. The joy of this card is that it’s a natural upgrade from Mano(1), and you can earn it by killing victory point monsters that other classes simply can’t do enough damage to.

Three damage guaranteed is enough to build a deck around. Have your allies take Stargazing, take First Watch or On the Hunt...Use "Get over here!" during enemy, upkeep, or mythos. You’re already playing Nathan to punch the crap out of horrid monsters. Make it easier, and recur it with your elder sign. You’ll appreciate cheap damage in guardian.

The usually prudish Sister bared her chest and fisted the Brotherhood Cultist as though the fate of the universe depended on it. Tag-teaming the cultist was the Huntress of Bast, trying to find an opening to impale the cultist with her arrowhead. A few frenetic, breathless moments later, Nephthys thrust in her fearsome weapon and sent the cultist straight to heaven.

The cultist's screams was soon joined by another as Rex splashed his juice all over an Acolyte next door.

Ironically, most interesting for Carolyn Fern, as a 0-cost way to permanently and efficiently deal with smaller enemies spawning atop you (potentially even combining it with Beat Cop or other testless damage to handle 3-health enemies), as she typically doesn't have many enemy management options (especially not so cheap and guaranteed). Theoretically very useful if you want the deck to have more independence from other investigators, or if there's no enemy fighter on the team (e.g. playing solo).

Plus, you know, it's amusing. Who needs orderlies now?

(And definitely a useful card if going for a gimmick build with Meat Cleaver.)