As some people mentioned, this card is a good replacement for Manual Dexterity. Same number of icons. It's worth remembering that Resigning does not provoke attacks of opportunities. If you are engaged with ennemies, have low health/sanity and are about to die, you can play this card even if you have no resources left to avoid getting a Physical or Mental trauma. That said, will not work with all scenarios. Would be interesting to see stats per campaign.
Play only if there is a scenario card with a 'resign' ability in play.
Resign. You get the hell out of here.
Initially this card seems kind of useless. Honestly I can't really comment on its applicability to your typical investigator but I do know of two investigators who can benefit a lot from it.
Zoey and Jenny can both get really screwed by their weaknesses if they drop in the last few rounds of the game. Zoey can get caught traveling all the way across the map in order to kill some jerk monsters and Jenny searching for Izzie in far off lands. This can be especially problematic in large maps or ones flush with monsters. If you only have a couple turns left in the campaign before the final Agenda procs you may not have that many actions to spare, and especially for these weaknesses they are on-par with being defeated anyway (which is significantly worse than any other investigators weakness penalty). In this method you can almost halve the number of actions required to fulfill these without screwing over your win condition.
It's not a perfect fix, but I'd consider a 1-of for these investigators to help them out alongside action-investments like Police badge or action-compression items like Cat Burgler.
Admittedly, I have not used this card in a deck yet.
If I were planning on using Charon's Obol, I might plan to use "I'm outta here!" more, since surviving a scenario without being defeated is that much more important in that case. However, I'm not sure how often I'd use it outside of that.
For investigators who can take it, I think that Elusive is the better alternative. Resign effects are normally printed on either Act cards or Location cards. If the Resign option is on the Act card, then there's no reason to use "I'm outta here!", since you could just use the Act's action normally. If the Resign option is on a Location card, you can use Elusive to get there (since it has the Fast keyword) and then resign. Elusive does cost 2 more resources, but it gives you a lot more flexibility in how you can use it. I think it is probably the better pick in most cases.
The two icons are situationally useful. If you're going to use card for 2 icons, though, you're probably better off just using Manual Dexterity for the card draw.
(Spoilers for the Carcosa cycle)
An interesting rules query for this Path to Carcosa Act card - would this card work for the card's Resign action regardless of the location of monsters and clues? My gut instinct is "yes" because the ability is "in play" - it exists constantly but is only useable under certain conditions. If that's true, then that would be the dream use for a card like this one.
(End Spoilers for the Carcosa cycle)
Ultimately, I think "I'm outta here!" is situational, and Elusive is able to cover those situations on its own (as well as quite a few more). For investigators like Rita Young that have access to "I'm outta here!" but not Elusive, it might be worth considering for those edge cases, but even then I would say there are probably cards that would be more regularly useful than this one.