I am writing my first review here as I want to check that idea:

That card to me could do wonder on Zoey Samaras with a type of deck that wants her to collect most enemies possible, for example with "Let me handle this!", On the Hunt, Taunt (and Upgrade 1/Upgrade 2).

Let's say that in this situation, Zoey gets around 3 enemies on her, attacks a full round, plays Hiding Spot so performing 3 Dodge at once.

The cherry on the cake, she gets automatically engaged again, bringing her 3 resources or 2 resources and 1 test-free damage with Zoey's Cross

And the more enemies she has on her, the merrier!

This card appears to suck really bad in the Innsmouth Conspiracy Campaign. It has mechanics which prevent its use, and then when you want to next use it, you are no longer repurchasing so can't use it then either.

Another enemy signature weakness. Looking at the two elements, the effect and the discard condition, we get:

The effect: Easy to hit, hard to damage, hard for Nathaniel to Evade, hits pretty hard. Normally, this is 3 actions to clear, although you can speed things up with Beat Cop, Counterpunch, or Survival Knife (probably with Bandolier). Guard Dog can also help. Handcuffs shenanigans are also a possibility. This card will pretty much cost you a turn, one way or another, but is rarely a danger to either the scenario or campaign.

The discard condition: Kill Tommy or put the cuffs on him; your choice.

All in all, this is an average signature weakness.

This is a fairly unique trauma signature weakness. Looking at the two elements, the effect and the discard condition, we get:

The effect: You take direct damage and trauma, mental or physical, your pick. Normally, this would be disastrous, but Calvin likes trauma, right up until he doesn't. There is no real mitigation, except not getting trauma outside of this card or, maybe, limiting drawing as much as possible. If the direct damage defeats you, you are getting 2 trauma, and once Calvin hits 6 trauma of either sort, you are out of the campaign. If you can get down Five of Pentacles, Until the End of Time, or any of the other soak assets, you can keep going with even very high trauma, but, if you draw this every scenario, you will be on very tight margins.

The discard condition: One and done. You take your trauma, and you take your chances.

All in all, this is an average signature weakness. It's managable but can end a campaign.

Another trauma signature weakness. Looking at the two elements, the effect and the discard condition, we get:

The effect: It drains Akachi's charges by forcing her to exhaust spells to build up 4 charges on this card before the end of the scenario, or face a physical trauma. Since Akachi usually has plans for those charges, this is a bad situation. While her Health is better than Roland's Sanity, physical trauma is still no joke and can end the scenario, especially since, like the whole suite of trauma weaknesses, if Akachi is defeated before getting the requisite charges on this card, she gets bonus trauma! On the upside, other investigators in her location can move charges as well, although it's not that common to have other spells with charges floating around. The largest problem with mitigation is that you want cheap spells with #+ charges, and they pretty much all take up Arcane slots that you already have plans for. You could use Sign Magick or Familiar Spirit to get more Arcane slots, but that is increasing the cost overall. Useful, low-cost spells include Alchemical Transmutation, Clarity of Mind, Healing Words, Mists of R'lyeh, and Song of the Dead, and Akachi's ability makes sure they have plenty of charges. One significant advantage to this card over other trauma weaknesses is that you will generally have two spells out, and Akachi can exhaust both of them in any free triggered ability window, allowing her to fill this weakness in two turns, drastically reducing the danger of a very late game draw. Now that Brand of Cthugha (4) exists, it would be pretty easy to siphon some of those 9 charges toward this, assuming you weren't the primary killer on your team.

The discard condition: None, but, if you get 4 charges on this card, you disable it (and it does not get discarded).

All in all, this is an average signature weakness.