| Name | Class | C. | Type | Icons | Traits | Set | Encounter |
|---|---|---|---|---|---|---|---|
| Sacred Covenant (2) | Guardian | Asset | Covenant. Blessed. | In Too Deep 110 | |||
| Safeguard (2) | Guardian | 2 | Asset | Talent. | Dark Side of the Moon 196 | ||
| Safeguard | Guardian | 2 | Asset | Talent. | Nathaniel Cho 10 | ||
| Say Your Prayers | Neutral | Skill | Desperate. | Echoes of the Past 116 | |||
| Scene of the Crime | Guardian | 2 | Event | Insight. Bold. | Threads of Fate 103 | ||
| Second Wind | Guardian | 1 | Event | Spirit. Bold. | The Boundary Beyond 149 | ||
| Second Wind (2) | Guardian | 0 | Event | Spirit. Bold. | The Feast of Hemlock Vale Investigator Expansion 32 | ||
| Self-Sacrifice | Guardian | Skill | Spirit. | A Thousand Shapes of Horror 157 | |||
| Shield of Faith (2) | Guardian | 2 | Asset | Spell. Blessed. | A Light in the Fog 221 | ||
| Shotgun (4) | Guardian | 5 | Asset | Item. Weapon. Firearm. | Core Set 29 | ||
| Shotgun (4) | Guardian | 5 | Asset | Item. Weapon. Firearm. | Revised Core Set 29 | ||
| Sled Dog | Neutral | 3 | Asset | Ally. Creature. | Edge of the Earth Investigator Expansion 127 | ||
| Sledgehammer | 3 | Asset | Item. Tool. Weapon. Melee. | Edge of the Earth Investigator Expansion 94 | |||
| Sledgehammer (4) | 3 | Asset | Item. Tool. Weapon. Melee. | Edge of the Earth Investigator Expansion 96 | |||
| Sleuth (3) | 3 | Asset | Talent. | Edge of the Earth Investigator Expansion 121 | |||
| Smoking Pipe | Neutral | 1 | Asset | Item. | The Miskatonic Museum 116 | ||
| Snipe (1) | 0 | Event | Tactic. | Edge of the Earth Investigator Expansion 87 | |||
| Solemn Vow | Guardian | 0 | Asset | Spirit. | The Dream-Eaters 20 | ||
| Something Worth Fighting For | Guardian | 3 | Asset | Talent. | The Secret Name 109 | ||
| Soul Sanctification (3) | Neutral | Asset | Ritual. | The Scarlet Keys Investigator Expansion 123 | |||
| Spiritual Resolve (5) | Guardian | 3 | Asset | Ritual. | Weaver of the Cosmos 323 | ||
| Springfield M1903 (4) | Guardian | 4 | Asset | Item. Weapon. Firearm. | Undimensioned and Unseen 226 | ||
| Stand Together (3) | Guardian | 0 | Event | Spirit. | The Essex County Express 148 | ||
| Stand Together | Guardian | 0 | Event | Spirit. | Nathaniel Cho 18 | ||
| Steadfast | Guardian | Skill | Innate. | The Circle Undone 22 | |||
| Stick to the Plan (3) | Guardian | Asset | Talent. | Black Stars Rise 264 | |||
| Strong-Armed (1) | Guardian | Skill | Innate. | The Feast of Hemlock Vale Investigator Expansion 31 | |||
| Survival Knife | Guardian | 2 | Asset | Item. Weapon. Melee. | The Forgotten Age 17 | ||
| Survival Knife (2) | Guardian | 2 | Asset | Item. Weapon. Melee. | Return to the Forgotten Age 2 | ||
| Sweeping Kick (1) | Guardian | 1 | Event | Spirit. Tactic. Trick. | Edge of the Earth Investigator Expansion 23 | ||
| Take the Initiative | Guardian | Skill | Practiced. Bold. | The Boundary Beyond 150 | |||
| Task Force | Guardian | 2 | Event | Tactic. Double. | The Feast of Hemlock Vale Investigator Expansion 27 | ||
| Taunt | Guardian | 1 | Event | Tactic. | The Dunwich Legacy 17 | ||
| Taunt (2) | Guardian | 1 | Event | Tactic. | The Dunwich Legacy 19 | ||
| Taunt (3) | Guardian | 1 | Event | Tactic. | Nathaniel Cho 30 | ||
| Teamwork | Guardian | 0 | Event | Tactic. | The Dunwich Legacy 18 | ||
| Telescopic Sight (3) | Guardian | 3 | Event | Item. Upgrade. | Union and Disillusion 230 | ||
| Tempt Fate | Neutral | 0 | Event | Fortune. Blessed. Cursed. | The Innsmouth Conspiracy 37 | ||
| Tetsuo Mori: Too Noble for His Own Good | Guardian | 3 | Asset | Ally. Police. | A Thousand Shapes of Horror 155 | ||
| The Black Cat: A Liar, or a Prophet, or Both (5) | Neutral | 2 | Asset | Ally. Avatar. Dreamlands. | Where the Gods Dwell 285 | ||
| The Council's Coffer: What’s in the Box? (2) | Neutral | 0 | Asset | Item. Relic. | For the Greater Good 196 | ||
| The Fool • 0: Unlimited Potential (3) | Neutral | 3 | Asset | Tarot. | Return to the Circle Undone 11 | ||
| The Hungering Blade: Calamitous Blade of Celephaïs (1) | Guardian | 3 | Asset | Item. Weapon. Melee. Relic. Cursed. | The Dream-Eaters 18 | ||
| The Red-Gloved Man: He Was Never There (5) | Neutral | 2 | Asset | Ally. Conspirator. | Lost in Time and Space 310 | ||
| The Star • XVII: You Have Been Chosen (3) | Guardian | 3 | Asset | Tarot. | Return to the Circle Undone 1 | ||
| Thermos | Neutral | 4 | Asset | Item. | The Depths of Yoth 274 | ||
| Timeworn Brand (5) | Neutral | 5 | Asset | Item. Relic. Weapon. Melee. | The Depths of Yoth 276 | ||
| Tinker | Guardian | 1 | Event | Insight. Upgrade. | The Feast of Hemlock Vale Investigator Expansion 28 | ||
| Toe to Toe | Guardian | 0 | Event | Spirit. Tactic. | Edge of the Earth Investigator Expansion 20 | ||
| Tool Belt | Neutral | 2 | Asset | Item. Clothing. | The Scarlet Keys Investigator Expansion 120 | ||
| Trench Coat | Neutral | 3 | Asset | Item. Clothing. | Heart of the Elders 203 | ||
| Trench Knife | Guardian | 1 | Asset | Item. Weapon. Melee. | The Unspeakable Oath 147 | ||
| True Grit | Guardian | 3 | Asset | Talent. | The Path to Carcosa 21 | ||
| Trusted | Guardian | 1 | Event | Upgrade. | The Forgotten Age 19 | ||
| Unexpected Courage | Neutral | Skill | Innate. | Core Set 93 | |||
| Unexpected Courage | Neutral | Skill | Innate. | Revised Core Set 93 | |||
| Venturer | Guardian | 4 | Asset | Ally. Wayfarer. | The Forgotten Age 18 | ||
| Versatile (2) | Neutral | Asset | Talent. | A Thousand Shapes of Horror 167 | |||
| Vicious Blow | Guardian | Skill | Practiced. | Core Set 25 | |||
| Vicious Blow | Guardian | Skill | Practiced. | Revised Core Set 25 | |||
| Vicious Blow (2) | Guardian | Skill | Practiced. Expert. | Lost in Time and Space 299 | |||
| Vicious Blow | Guardian | Skill | Practiced. | Nathaniel Cho 19 | |||
| Warning Shot | Guardian | 2 | Event | Tactic. Trick. | Union and Disillusion 229 | ||
| Well Prepared (2) | Guardian | 2 | Asset | Talent. | The Boundary Beyond 151 | ||
| Well-Dressed | Neutral | Skill | Practiced. Fortune. | The Feast of Hemlock Vale Investigator Expansion 130 | |||
| Well-Maintained (1) | Guardian | 0 | Event | Upgrade. | The Wages of Sin 152 | ||
| Wolf Mask: The Moon's Sire | Guardian | 1 | Asset | Item. Charm. Mask. | The Feast of Hemlock Vale Investigator Expansion 23 |